DIFFERENTIAL REGULATION OF CIRCULATING CARDIAC NATRIURETIC PEPTIDES IN HUMAN ACUTE DECOMPENSATED HEART FAILURE: EVIDENCE FOR A SELECTIVE AND RELATIVE ATRIAL NATRIURETIC PEPTIDE DEFICIENCY

Shawn Reginauld,Valentina Cannone,Denise M. Heublein,Seethalakshmi Iyer,Christopher G. Scott,Jeson S. Sangaralingham,John C. Burnett

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2018）

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摘要

The endocrine heart releases Atrial and Brain Natriuretic Peptide (ANP and BNP) as protective mechanisms in heart failure (HF). While ANP is a more potent activator of Guanylyl Cyclase A than BNP, ANP is more susceptible to catabolism. Although BNP and biologically inactive NT-proBNP are well

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