Can hi-jacking hypoxia inhibit extracellular vesicles in cancer?

•EVs contribute to numerous pathological problems associated with cancer.•EVs from noncancerous cells play parts in normal communication between cells.•Blocking all EV release in the body could cause as many problems as it prevents.•Hypoxia, a feature of solid tumours, contributes to EV release, contents and activity.•Targeting hypoxia should inhibit EVs and their influences in cancer.