GIT2 : a keystone in ageing and age-related disease

Jaana van Gastel,Jan Boddaert,Areta Jushaj,Richard T. Premont,Louis M. Luttrell,Jonathan Janssens,Bronwen Martin,Stuart Maudsley

Ageing Research Reviews（2018）

引用 23|浏览42

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摘要

•Highly complex physiological processes are controlled by nuanced systemic protein networks.•GIT2 acts as an integrator protein for hallmark ageing processes.•GIT2 genomic deletion models show multiple signs of ageing and age-related disorders.•Regulation of GIT2 expression/functionality may allow reversal of age-related disorders.

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关键词

AD,ArfGAP,AT,ATM,ATP,BRCA1,CNS,DDR,DSB,EGF,GIT2,GPCR,Ins,IGF1,IL,NF-κB,OB,OC,PARP,PIX,RANK,ROS,RUSC2,T2DM,TLR,TNFα,WT

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