Labels of aberrant Clusters of Differentiation gene expression in a compendium of systemic lupus erythematosus patients

bioRxiv(2018)

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摘要
This author manuscript serves as an extended annotation of gene expression for all known clusters of differentiation (CD) within a compendium of systemic lupus erythematosus (SLE) patients. The overarching goal for this line of research is to enrich the CD transcriptome with perspectives of upstream gene expression features. Within our study, CD gene expression features (n=351) were labeled as 9aberrant9 or 9non-aberrant, with 9aberrant9 being further delineated as 9low9 or 9high9. Gene expression was stratified at 20 and 80 percentiles, with low expression being between 0 and 20, average between 20 and 80, and high between 80 and 100. Some CDs required minor shifting of two-tailed thresholds, while others required binary transformation to characterize the CD feature. Detailed labelling of aberrance for all CD features (n=351) identified within the SLE Compendium is provided, including histograms of CD gene expression distribution and descriptive statistics of expression and variation.
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