PBI-4050, A NOVEL FIRST-IN-CLASS AGENT, REDUCES PULMONARY HYPERTENSION, LUNG REMODELING AND RIGHT VENTRICULAR DYSFUNCTION IN HEART FAILURE

Jocelyn Dupuis,Quang T. Nguyen,Martin G. Sirois,Angelino Calderone,Jean-Claude Tardif,Yanfen Shi, Alexandre Laverdure,Brigitte Grouix,Lyne Gagnon

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2018）

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摘要

Heart failure with reduced ejection fraction (HFrEF) causes lung remodeling characterized by myofibroblasts proliferation and fibrosis leading to a restrictive lung syndrome with pulmonary hypertension (PH) and right ventricular (RV) dysfunction. PBI-4050 is a first-in-class synthetic analog with

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关键词

reduces pulmonary hypertension,pulmonary hypertension,heart failure,right ventricular dysfunction,lung remodeling,first-in-class

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