Case of alopecia universalis associated with alemtuzumab treatment in MS

Alemtuzumab (Lemtrada®) is a monoclonal antibody recognizing CD52 that selectively depletes T- and B-lymphocytes1 and is indicated for the treatment of relapsing-remitting MS (RRMS). Although it is highly efficacious, its use is associated with secondary autoimmune phenomena, such as thyroid dysfunction, immune thrombocytopenia, and glomerulonephritis.2