Recommendations for enterovirus diagnostics and characterisation within and beyond Europe

Heli Harvala,Eeva Broberg,Kimberley Benschop,Nataša Berginc,Shamez Ladhani,Petri Susi,Claus Christiansen,James McKenna,David Allen, Phoebe Makiello, Georgina McAllister,Mirabelli Carmen,Katherina Zakikhany,Robert Dyrdak,Xiaohui Chen Nielsen,Tina Vasehus Madsen,Joel Paul,Catherine Moore,Karin von Eije,Antonio Piralla,Mieke Carlier,Laura Vanoverschelde,Randy Poelman,Andrés Anton,F. Xavier López-Labrador,Laura Pellegrinelli,Kathrin Keeren,Melanie Maier,Hayley Cassidy,Stavros Derdas,Carita Savolainen-Kopra,Sabine Diedrich,Svein Arne Nordbø,Javier Buesa,Jean Luc Bailly,Fausto Baldanti,Andrew J. Macadam,Audrey Mirand,Susanne G. Dudman,Isabelle Schuffenecker,Seilesh Kadambari,Johan Neyts,Michael Griffiths,Jan Richter, Cristina Margaretto, Sheila Govind,Ursula Morley,Ortwin Adams,Sidsel Krokstad,Jonathan Dean,Margarita Pons-Salort, Birgit Prochazka,María Cabrerizo,Manasi Majumdar,Gaia Nebbia,Maryse Wiewel,Simon Cottrell,Peter V. Coyle,Javier Martin,Catrin E. Moore,Sofie Midgley,Peter Horby,Katja C. Wolthers,Peter Simmonds,H.G.M. Niesters,Thea Kølsen Fischer

Journal of Clinical Virology（2018）

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摘要

•European Non-polio Enterovirus Network established.•Collect respiratory, stool and CSF samples for EV testing from patient with neurological infection.•Sensitive PCR method should be used to diagnose EV infection.•Sequencing of VP1 capsid protein gene is recommended for EV typing.•Standardased laboratory diagnostics and characterisation key for effective surveillancce.

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关键词

Enterovirus,Detection,EV typing,Neurological infection,European non-polio enterovirus network (ENPEN),Diagnostics

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