Anti-metastatic activity of Agrocybe aegerita galectin (AAL) in a mouse model of breast cancer lung metastasis

Qing Yang,Yalin Yin,Yongfu Pan,Xiangdong Ye,Bo Xu,Wenhui Yu,Haolong Zeng,Hui Sun

Journal of Functional Foods（2018）

引用 9|浏览12

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摘要

•AAL preferentially accumulated in the lung of mice after tail vein injection.•AAL exhibited anti-metastatic activity on a mouse model of 4T1 lung metastasis.•The carbohydrates recognition determined the bioactivity of AAL.•MMP-9 expression and activity were involved in the anti-metastatic effect of AAL.

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关键词

Agrocybe aegerita galectin,Anti-metastatic activity,Apoptosis,ICAM-1,MMP9

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