Sv2b Can Regulate Bace1 Localization In The Hippocampus

M. Miyamoto,A. Kuzuya,Y. Noda,Kengo Uemura,M. Asada-Utsugi, Y. Fukusumi, H. Kawachi, S. Ito,Ryosuke Takahashi,Ayae Kinoshita

JOURNAL OF THE NEUROLOGICAL SCIENCES（2017）

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摘要

Background: Aβ is produced and released locally at synapses in response to synaptic activity. Interestingly, BACE1 responsible for Aβ generation has been found to preferentially localize to presynaptic terminals including synaptic vesicles. However, how BACE1 affects activity-dependent Aβ production at the synapse remains unknown.

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bace1 localization

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