Serum magnesium in association with parathyroid hormone levels in routine hemodialysis patients

AbstractIntroduction: The homeostasis of magnesium (Mg) is perturbed in chronic kidney disease. It has been supposed that plasma Mghas a principal role to regulate the secretion of parathyroid hormone (PTH). Plasma Mg is capable of modulating secretion of PTH.Recent investigations showed that low serum Mg levels in patients with kidney disease have been linked to increased mortality.Objectives: The aim of this study was to determine the relationship between serum Mg and PTH levels in hemodialysis patients.Patients and Methods: This cross-sectional study was conducted on 56 hemodialysis patients in hemodialysis center of Hajar hospitalof Shahrekord in 2015. Regular hemodialysis patients who had at least three months history of dialysis were enrolled to the study.The serum levels of Mg, calcium, phosphorus, intact PTH (iPTH), alkaline phosphatase, albumin and bicarbonate were measured.Results: In this study, 61.5% of the 52 patients were male. Mean ± standard deviation (SD) of patients’ age was 60.5 ± 17.7 yearswith median of 63 years old. The average duration of dialysis was 44±39.5 months (median 36 months). Additionally the dialysisdose was 517 ± 479 weeks (median; 414 weeks). Mean ± SD of serum iPTH and Mg were 360.1 ± 238.2 pg/mL and 2.2 ± 0.2 mg/mLrespectively. In this study we found a significantly positive correlation of iPTH with serum Mg levels (r=0.28, P=0.04).Conclusion: This study shows impact of Mg on parathormone secretion. Our findings require further investigations with larger andmulticentric studies.Please cite this paper as: Fooladgar M, Malekpour A, Asgari-Savadjani S, Mardani S. Serum magnesium in association withparathyroid hormone levels in routine hemodialysis patients. J Parathyr Dis. 2018;6(1):13-15. DOI: 10.15171/jpd.2018.05.Copyright © 2018 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the termsof the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium,provided the original work is