Histonvarianten - Gleiche Gene bedeuten nicht gleiches Schicksal

Chromatin is one of the most significant structures to regulate gene expression. Active deposition and incorporation of specialized histone variants can lead to severe alterations in gene expression, cell cycle progression and embryonic development. Further, deregulation or mutations of histone variants are often implicated in diseases, most notably cancer development. Our work focuses on the discovery of novel human histone variants and variant-interactors to better understand fundamental epigenetic processes.