Non-Invasive Liver Cancer Ablation Using Histotripsy In An In Vivo Murine Hepatocellular Carcinoma (Hcc) Model

Current liver cancer ablation methods are mainly thermal-based and inherently exhibit inconsistent tissue ablation due to irregular heat dissipation. Histotripsy is a non-thermal ultrasound (US) ablation method that fractionates tissue through the precise control of acoustic cavitation. This paper studies the feasibility and chronic effects of non-invasive histotripsy for liver cancer ablation in an in vivo murine HCC model.