Prognostic Impact Of The Presence Of Copd In Patients With Nsclc Under Conventional Systemic Chemotherapy

Background: It was thought that the major cause of pulmonary adenocarcinoma is gene mutations, including epidermal growth factor receptor (EGFR). However, the relationship between epidermal growth factor receptor (EGFR) mutation and histological classification of lung adenocarcinoma has not yet fully evaluated. Aims: To investigate the relationship between epidermal growth factor receptor (EGFR) mutation and histological classification of lung adenocarcinoma according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS). Methods: Prospective, Cross-sectional descriptive study on 93 patients of lung adenocarcinomas was diagnosed by histopathology at Respiratory center Bach Mai hospital: from 1/2014 to 9/2015. Results: EGFR mutation (51.6%), in females (75.0%) was higher than that of males (36.8%), The prevalence of non-smokers (71.8%) was higher than smokers (37.0%) (P<0.05). Mutations occurred more frequently in the subtypes: acinar (47.7%), papillary (57.9%), lepidic (60%), papillary (57.1%), no difference by age group, location, tumour margin, size of the tumour with mutations. Conclusions: EGFR mutations were correlated with gender, smoking history and histological subtypes of lung adenocarcinoma by classification of the IASLC/ATS/ERS 2011.