First-in-human pet study with 18f-am-pbb3 and 18f-pm-pbb3

deposition. Results:Elevated neuroticism scores were significantly associated with higher tau accumulation in the amygdala (p1⁄4.003), entorhinal cortex (p1⁄4.031), and inferior temporal cortex (p<.001) (Figure 2a). In contrast, extroversion, openness, agreeableness, and conscientiousness were not associated with tau deposition for any of these regions (Figure 2b-e). After additionally adjusting for b-amyloid, results remained essentially unchanged (Table 1). Conclusions:Our results indicate that increased neuroticism is associatedwith higher tau pathophysiology in AD-vulnerable regions in CN participants. These effects were not driven by b-amyloid, suggesting a unique relationship between neuroticism and tau levels. High neuroticism scores are associated with increased levels of stress, which in turn may serve as a potential risk factor for tau accumulation. Alternatively, personality has been shown to change with the onset of AD, thus increased tau levels may affect neuroticism scores. While, future longitudinal studies are needed to determine directionality, our findings suggest early associations between neuroticism and tau accumulation in CN adults.