An epitope of limited variability as a novel influenza vaccine target
bioRxiv(2018)
摘要
Antigenic targets of influenza vaccination are currently seen to be polarised between (i) highly immunogenic (and protective) epitopes of high variability, and (ii) conserved epitopes of low immunogenicity. This requires vaccines directed against the variable sites to be continuously updated, with the only other alternative being seen as the artificial boosting of immunity to invariant epitopes of low natural efficacy. However, theoretical models suggest that the antigenic evolution of influenza is best explained by postulating the existence of highly immunogenic epitopes of limited variability. A corollary of this model is that a influenza vaccine may be constructed by identifying such protective epitopes of low variability and these vaccines would also have the potential to protect against newly emerging influenza strains. Here we report the identification of such an epitope of limited variability in the head domain of the H1 haemagglutinin protein that could be exploited to produce a universal vaccine for the H1 subtype of influenza A.
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