Enhancing ganglioside species detection for MALDI-TOF imaging mass spectrometry in negative reflectron mode

Ethan Yang,Martin Dufresne,Pierre Chaurand

International Journal of Mass Spectrometry（2019）

引用 15|浏览4

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摘要

•A sample preparation method for enhanced imaging MS of gangliosides is proposed.•The method requires ammonium formate deposition then matrix coating by sublimation.•Sample storage for 24h at −20°C further increases ganglioside ion yields.•Imaging MS data shows on average 15-fold improvements in ganglioside ion yields.

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关键词

Imaging mass spectrometry,Gangliosides,Glycosphingolipids,Sample preparation,MALDI,High resolution

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