Alpha-glucosidase and alpha-amylase inhibiting thiodiketopiperazines from the endophytic fungus Setosphaeria rostrata isolated from the medicinal plant Costus speciosus in Sri Lanka

Ryan M. Centko,Pamoda B. Ratnaweera,Christina Tysoe,Stephen G. Withers,E. Dilip de Silva,Raymond J. Andersen

Phytochemistry Letters（2017）

引用 22|浏览12

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摘要

•Five thiodiketopiperazines were isolated from the endophyte Setosphaeria rostrata.•1D and 2D-NMR studies established that three of them are new.•Known metabolite, exserohilone, exhibited alpha-glucosidase inhibitory activity.•One new compound, rostratazine B, inhibited porcine pancreatic alpha amylase.

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关键词

Thiodiketopiperazines,Setosphaeria rostrata,Endophytic fungi,Costus speciosus,α-Glucosidase inhibitory activity,Porcine pancreatic alpha amylase inhibitory activity

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