THU0281 Long-term prognosis and predictingfactors of chinese patients with systemic lupus erythematosus: a multi-center cohort study from cstar registry

Objectives To investigate the long-term outcomes, both mortality and damage, and related prognostic factors of patients with systemic lupus erythematosus (SLE) in the CSTAR (Chinese SLE Treatment and Research group) registry cohort. Methods All of the patients were enrolled from April 2009 to February 2010. They were followed up at clinic and were telephone interviewed at the endpoint. Demographic data, clinical manifestations, activity (SLEDAI-2K), damage scores (SLLIC/Damage Index), and medications were collected. Data were censored at the last clinic visit or telephone interview. Survival rates were studied by Kaplan-Meier method, and COX proportional hazard model was adopted to perform the analysis of predicting factors for mortality. Results A total of 2104 patients were recruited at baseline, and 1494 patients were successfully followed up. The cumulative 1, 3 and 5-year survival ratesfrom diagnosis were 99.0%, 98.1% and 97.1%. 78 patients died during follow-up, and the main death causes were infection (34.6%), active disease (26.9%), cardiovascular and cerebrovascular events (6.41%) and malignancy (5.13%). At entry, 247 patients presented with irreversible organ damage and it increased to 398 patients at the endpoint. The major accumulated organ damages were renal (25.9%), musculoskeletal (20.2%), neuropsychiatric (12.4%), and pulmonary (10.8%) damage. Cox regressionshowed that male, late onset age (≥50y), onset to diagnosis time ≥1 year, previous organ damage, renal involvement, pulmonary arterial hypertension, neuropsychiatric involvement, serositis and the number of involved organ systems ≥3predict for higher mortality. Conclusions Long-term survival rates have improved for Chinese SLE patients. Early diagnosis, preventing fromthe emerging systemic organ involvements and organ damagecould be the treating target for the management of SLE patients in China. Disclosure of Interest None declared