Pannexin-1 channels in epilepsy

•Panx1 expression is raised in several animal models of seizure, and is localized to regions critical for seizure development.•Panx1 channels appear to have a multi-faceted and critical role in epileptogenesis; including contributions to P2X receptor activation, ATP release, glutamatergic signalling, potassium dynamics.•Studies suggest that blocking Panx1 channels reduces excitability, can be anticonvulsant, and may be a promising target for future therapies.