Increased regulatory T cells in pediatric acute appendicitis

Appendectomy of an inflamed appendix has been reported to be protective in the pathogenesis of ulcerative colitis (UC) in both mice and human (1, 2). In mice, the contribution of a suppressive T cell subset has been described. However, no human prospective study has investigated the generation of those protective cells. Using immunofluorescence microscopy we evaluate for the first time the generation of suppressor T cells during pediatric acute appendicitis in a small control-matched cohort study.This article is protected by copyright. All rights reserved.