Current challenges and future prospects in chromatographic method development for pharmaceutical research

Frederick T. Mattrey, Alexey A. Makarov,Erik L. Regalado, Frank Bernardoni,Margaret Figus, Michael B. Hicks,Jinjian Zheng, Lin Wang,Wes Schafer, Vincent Antonucci,Simon E. Hamilton, Kerstin Zawatzky,Christopher J. Welch

TrAC Trends in Analytical Chemistry(2017)

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摘要
A survey of different strategies for chromatographic method development in pharmaceutical research and development is presented. Owing to the widespread utilization of chromatography within diverse areas of pharmaceutical research, a variety of strategies for method development have arisen. We survey the current state of the art, discuss recent trends and approaches and highlight future prospects and capability gaps.
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关键词
Liquid chromatography,Supercritical fluid chromatography,Method development workflow,Method screening,Analytical method modeling,Quality-by-design,Allotrope Foundation,Pharmaceutical analysis
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