In-vitro Antihistaminic and Antispasmodic Study of Aqueous Extract of Leaves of Bryophyllum pinnatum L.

The present study was undertaken to evaluate in-vitro antihistaminic and anti-spasmodic activity of aqueous extract of leaves of Bryophyllum pinnatum L. by using isolated goat tracheal chain and chicken ileum preparation. The cumulative concentration response to histamine and Acetyl choline in the absence and presence of aqueous extract were recorded with a kymograph. The aqueous extract decreases the goat tracheal contraction and ileum contractions induced by histamine and Acetyl choline in dose dependent manner as compared with standard drug Chlorpheniramine Maleate and Atropine sulphate respectively. This revealed that aqueous extract of leaves of Bryophyllum pinnatum L possess a high degree of antihistaminic and spasmolytic activity by blocking histaminic and cholinergic receptors.