Increasing Skeletal Muscle Mass Could Prevent Stroke

Objective: To evaluate the correlation between skeletal muscle mass and stokeBackground: It is known that sarcopenia is associated with cerebrovascular disease. However, it is unknown whether increased skeletal muscle mass (SMM) can prevent stroke. This study was designed to establish an association between SMM and brain white matter changes and/or silent infarction (WMC/SI).Methods: This was a community-based, cross-sectional study supported by the regional government. SMM measurements and brain computed tomography were performed in 722 stroke-free and dementia-free subjects (aged 50-75 years). Subjects were divided into four groups by SMM checked by bioelectrical impedance analysis. Odd ratios (ORs) of WMC/SI about higher SMM groups for the lowest SMM group were calculated. After 4 groups analysis, subjects were divided 2 groups and analyzed separately by gender.Result: In four groups analysis, unadjusted ORs of 2nd to 4th quartile were 0.616 (95[percnt] confidence interval [CI] 0.372-1.022 P=0.085), 0.290 (CI 0.159-0.530 Pu003c0.001) and 0.209 (CI 0.108-0.403 Pu003c0.001). Adjusted ORs for age, hypertension, diabetes mellitus, education, hypercholesterolemia, and smoking were 0.994 (CI 0.513-1.740 P=0.085), 0.669 (CI 0.329-1.362 P=0.268) and 0.464 (CI 0.219-0.984 P=0.045). In two group analysis, unadjusted ORs for the higher muscle mass group was 0.313 (CI 0.200-0.491, P u003c 0.001). After adjustment, the OR were 0.577 (CI 0.340-0.979, P = 0.042). Seperating gender, adjustment OR were 0.351 (CI 0.141-0.869, P = 0.024) in men and 0.771 (CI 0.391-1.519, P = 0.452) in women.Conclusion: High SMM group had low WMC/SI, especially in men. Increased SMM by muscle strengthening exercise may prevent stroke. Disclosure: Dr. Minn has nothing to disclose. Dr. Suk has nothing to disclose. Dr. Koh has nothing to disclose. Dr. Hwang has nothing to disclose. Dr. Park has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Song has nothing to disclose.