Polymer resonators sensors for detection of sphingolipid gel/fluid phase transition and melting temperature measurement

•We have validated an effective approach to detect the sphingomyelin gel/fluid phase transition at very low concentration lipid by means of a low-cost biophotonic sensor developed by way of cheap processes as hybrid silicon/silica/polymer resonators. Then, for the first time:•The dynamic evolution of the sphingomyelin lipid phase transition was assessed by such photonics sensors: the ability to detect their own gel/fluid transition phase and melting temperature has been demonstrated.•The equilibrium of the regime of the resonators was highlighted as being broken by the dynamic of the sphingomyelin and its own phase transition prior relevant detection.•Measurements were obtained with a mass product factor about fourteen millions times lower than that of the conventional method called differential scanning calorimetry.