Mouse models of acute and chronic hepacivirus infection

    Science, pp. 204-208, 2017.

    Cited by: 25|Bibtex|Views34|

    Abstract:

    An estimated 71 million people worldwide are infected with hepatitis C virus (HCV). The lack of small-animal models has impeded studies of antiviral immune mechanisms. Here we show that an HCV-related hepacivirus discovered in Norway rats can establish high-titer hepatotropic infections in laboratory mice with immunological features resem...More

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