omniCLIP: Bayesian identification of protein-RNA interactions from CLIP-Seq data

High-throughput immunoprecipitation methods to analyze RNA binding protein-RNA interactions and modifications have great potential to further the understanding of post-transcriptional gene regulation. Due to the differences between individual approaches, each of a diverse number of computational methods can typically be applied to only one specific sequencing protocol. Here, we present a Bayesian model called omniCLIP that can be applied to data from all protocols to detect regulatory elements in RNAs. omniCLIP greatly simplifies the data analysis, increases the reliability of results and paves the way for integrative studies based on data from different sources.