Abstract 310: Aerobic Exercise Training Improves Blood Pressure Variability in Obese Female Mice.

Background: Clinical issues related with obesity and diabetes are focused not only on metabolic dysfunctons, but also on cardiovascular pathologies which are the likely cause of morbidity and mortality in these patients. In this sense, blood pressure variability (BPV) has been reported to be associated with an adverse cardiovascular prognosis. Ob/ob mice have been used as a model of type 2 diabetes and obesity. However, the effects of aerobic exercise training on cardiovascular parameters in this model are unknown. Objective: The aim of this study was to evaluate the blood pressure variability in trained youth obese mice. METHODS: Female ob/ob mice (4 weeks) were randomized into sedentary (OS, n=11) or trained (OT, n=8) (treadmill,5 days/w, 60 min/d, during 8 wks) groups. Blood glucose was measured by reagent strips. Arterial pressure signals were recorded using a data acquisition system. Results: The OT group had higher exercise capacity compared to the OS group. OT group had reduced body weight and blood glucose (45±2g, 133±3 mg/dL) compared to OS group (50±2g e 169±8 mg/dL). Mean arterial pressure and heart rate were similar between groups (OS: 106 ± 4mmHg and 513± 18bpm vs. OT: 104 ± 6 mmHg and 514±28bpm). The BPV and the low frequency band of BPV were higher in the OS (23 ± 3mmHg2 and 7 ± 1 mmHg2) compared to the OT group (15 ± 2 mmHg2 and 5 ± 1 mmHg2). Moreover, the spontaneous baroreflex sensitivity, represented by alpha index, was lower in the sedentary group (1.2 ± 0.3 ms/mmHg) compared to the trained group (1.9 ± 0.2 ms/mmHg). Conclusion: Our results suggest that early physical training in obese mice can be effective in attenuating the increase in weight and blood glucose in addition to improving blood pressure variability in these animals. Sources of funding: FAPESP,CNPq