Analysis Of The Acute Radiation-Induced Toxicity In Relation To The Serum Il-8 Level In Postmenopausal Women With Receptor-Positive Breast Cancer Receiving Adjuvant Radiotherapy With Concomitant Or Sequential Anastrozole.
JOURNAL OF CLINICAL ONCOLOGY(2014)
摘要
e11558 Background: To compare acute skin reaction occurrence rate and serum IL-8 level in postmenopausal hormone receptor-positive patients with concurrent or sequential anastrozole with radiotherapy. Compare the hematologic toxicity, radiation-induced lung injury and long-term outcome in these patients. Methods: From January 2, 2011 to June 20, 2012, 80 postmenopausal hormone receptor-positive breast cancer patients were enrolled in this prospective study. All patients received adjuvant radiotherapy in the Department of Radiation Oncology, Fudan University Shanghai Cancer Center and were randomly classified as concurrent group (n=40) in which hormonal therapy with anastrozole combined concurrently with radiotherapy, and sequential group (n=40) in which hormonal therapy with anastrozole were followed after completion of radiotherapy. Treatment complications, prognostic outcomes and serum IL-8 level (four weeks after the start of radiotherapy) were followed up and analyzed. Results: The median follow-up ti...
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