Discovery of a potent angiotensin converting enzyme inhibitor via virtual screening

Zhipeng Ke,Zhenzhen Su,Xinzhuang Zhang,Zeyu Cao,Yue Ding,Liang Cao,Gang Ding,Zhenzhong Wang,Haichun Liu,Wei Xiao

Bioorganic & Medicinal Chemistry Letters（2017）

引用 25|浏览14

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摘要

•Virtual screening method was utilized to search a natural compounds database to obtain ACE inhibitors.•36 natural compounds from hits were tested the inhibitory activity of ACE kinase.•To discover three leads against ACE, such as Licochalcone A, Echinatin and EGCG.•Structure-activity relationship was analysis in order to give some clues for the further research.

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关键词

Angiotensin converting enzyme,ACE,Drug discovery,Virtual screening,In silico

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