Clinical Characteristics Of Adult Alveolar Rhabdomyosarcoma (Arms) Patients (Pts) On Front-Line Therapies: An Md Anderson Cancer Center (Mdacc) Series.

11069Background: ARMS is considered to be one of the most aggressive pediatric malignancies. Adults with ARMS notoriously experience inferior outcomes. Our goal was to define our adult population with ARMS and review their outcomes on front-line systemic therapies. Methods: Adult ARMS pts over the age of 18 years (y) treated at MDACC from 2004 to 2015 were identified from our registry. Descriptive statistics and survival analysis were performed via multivariate analysis. Results: 43 pts were identified. Median age at diagnosis was 31 y (range (R) 18 to 69 y). 51% were male. 26 pts (60%) were Caucasian, 10 pts (23%) were Latino, 5 pts (12%) were Asian and 2 pts (5%) were African-American. The most common primary site was the parameningeal space (25 pts; 58%). The majority were classified with IRSG stage IV (37%) or III disease (47%). The majority were classified with group IV (37%) or III (56%). By COG clinical risk, 27 pts (63%) and 16 pts (37%) were intermediate and high, respectively. N1 disease was not...