Prenatal diagnosis of transient abnormal myelopoiesis in three fetuses with Down syndrome: heterogeneous ultrasonographic findings and outcomes

Transient abnormal myelopoyesis (TAM) is diagnosed in approximately 10% of babies with Down syndrome (DS), progressing to life-threatening illness in 20% of them. We describe three cases of TAM characterized by heterogeneous ultrasonographic findings and outcomes.The first case was a 27-year-old woman at 32 weeks and 5 days with severe fetal hepatosplenomegaly: liver longitudinal diameter of 78 mm, u003e2SD (1) and spleen longitudinal diameter of 60 mm, u003e2SD (2) (Figure 1).