Weight Trajectories During First Two Years Of Endocrine Treatment: Premenopausal Compared To Postmenopausal Early Breast Cancer Survivors.

e12069Background: Obesity and weight gain in breast cancer survivors (BCS) can impact prognosis, survival, and quality of life. Women who were premenopausal (PreBCS) or postmenopausal (PostBCS) at BC diagnosis are compared regarding weight change during the first 2 years of endocrine treatment (ET) and factors associated with u003e 2kg weight gain. Methods: Data were gathered by retrospective chart review, with weights assessed by nursing staff during routine clinic visits. Chi-squared and t-tests were used to compare PostBCS and PreBCS characteristics, and log-binomial regression models to evaluate factors associated with u003e 2kg weight gain. Results: In a final sample of N = 447 BCS, 33% were PreBCS (mean age 44) and 67% were PostBCS (mean age 65). PreBCS had lower BMI at diagnosis (p = 0.003), lower proportion of white (p = 0.04), fewer comorbidities (p u003c 0.0001); higher stage (p u003c 0.0001), grade (p = 0.008), node positive (p u003c 0.0001), PR positive (p = 0.03), and HER2 positive (p = 0.03) BC tumors; higher p...