THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro

Hiromi Shiratori,Carmen Feinweber,Sonja Luckhardt,Bona Linke,Eduard Resch,Gerd Geisslinger,Andreas Weigert,Michael J. Parnham

Molecular Immunology（2017）

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摘要

•THP-1 Mφ elicited unique polarization profiles in comparison to PBMC Mφ.•Selection of time points is critical for Mφ polarization studies.•Phagocytosis capacity was not distinct between polarized THP-1 and PBMC Mφ.•THP-1 may be of greatest use in studies involving M1 polarization.

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关键词

ACTB,CCL2,CCL18,CCL22,CCR7,CD,COX2,IFNγ,IL1β,IL-4,IL-10,IRF4,IRF5,Jmjd3,LPS,Mφ,MRC1,PBS,PMA,PPARγ,PBMC Mφ,RelA,RelB,RPL37A,SOCS1,SOCS3,SSP,TGFβ1,THP-1 MΦ,TLP,TNFα

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