Complement in renal transplantation : The road to translation

Neeltina M. Jager,Felix Poppelaars,Mohamed R. Daha,Marc A. Seelen

Molecular Immunology（2017）

引用 37|浏览16

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摘要

•Complement is already activated in the donor and negatively impacts renal graft outcome.•Complement production during preservation can be used as a marker for post-transplant renal function.•Complement inhibition during ischemia-reperfusion reduces renal inflammation and apoptosis.•Complement-targeted therapeutics could be a possible treatment in rejection.

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关键词

ABMR,aHUS,AP,DBD,DCD,DSA,C1-INH,C3,CDC,CL-11,CP,CR2,Crry,sCR1,DAF,HMP,IRI,LP,LPS,mAb,MAC,MASP,MBL,MCP,NMP,RAG-1,siRNA,UW,Y-CVF

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