Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia

Genetic alternation of the mixed lineage leukemia ( MLL ) gene can be found in up to 10% of acute myeloid leukemia (AML).[1][1],[2][2] Similar to MLL fusions and MLL partial tandem duplication (PTD), MLL amplification ( MLL (n)) is reported in approximately 1% AML and myelodysplastic syndrome (MDS)