Role Of Radiotherapy In Patients With Early-Stage Diffuse Large B Cell Lymphoma Who Had Achieved Complete Remission After Chemotherapy.

e19502 Background: In the rituximab era, results of randomized trials and relevant studies focused on the role of consolidation radiotherapy (RT) in stage I–II diffuse large B cell lymphoma (DLBCL) were very few. The objective of this study is to investigate the role of consolidation radiotherapy (RT) in patients with stage I–II diffuse large B cell lymphoma (DLBCL) who had achieved complete remission after chemotherapy. Methods: Between January 2005 and December 2012, data for 376 patients with early stage DLBCL in complete remission after receiving cyclophosphamide, doxorubicin/epirubicin, vincristine and prednisone (CHOP) or rituximab plus CHOP (R-CHOP) for at least three cycles were analyzed retrospectively. The median age was 53 years. Patients were divided into four groups: the R-CHOP group (93 patients), the R-CHOP+RT group (78 patients), the CHOP group (107 patients) and the CHOP+RT group (98 patients). All patients used Involved –field radiotherapy and the total dosage ranged from 30 Gy to 56Gy. ...