Breath analysis for early detection of lung cancer.

7048 Background: Lung cancer (LC) is the leading cause of cancer death worldwide. Early detection is critical to reduce LC related mortality. Breath analysis can be used as a non invasive diagnostic tool in conjunction with CT screening. We assessed the diagnostic value of breath volatile organic compounds (BVOCs) in the alveolar breath of female non-small cell lung cancer (NSCLC) patients. Methods: This is a prospective case-control study that enrolled newly diagnosed NSCLC and cancer-free female controls. The study aims: 1) To compare the BVOC signature in female NSCLC patients to a control group without LC 2) To compare the BVOC signature between NSCLC and breast cancer (BC) patients. The study was restricted to women because the pilot data was generated from female subjects with BC. Consenting eligible patients provided a total of five deep breath samples into a proprietary breath sampler developed at the Georgia Tech Research Institute (GTRI) for collecting alveolar breath. Breath samples were collec...