Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative

R.J. Edmondson,E.J. Crosbie, M. Nickkho-Amiry,A. Kaufmann,E. Stelloo,H.W. Nijman,A. Leary,A. Auguste,L. Mileshkin,P. Pollock,H.J. MacKay,M.E. Powell,T. Bosse,C.L. Creutzberg,H.C. Kitchener

Gynecologic Oncology（2017）

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摘要

•We used markers of the p53 pathway to refine existing stratifications of endometrial cancer.•We showed that mdm2 and p63 are useful markers to further classify this disease.•This is particularly important in the copy number low tumours.

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关键词

Endometrial cancer,Molecular profiling,Prognosis,p53,p21,pp63,L1CAM,Pole

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