Molecular cloning and characterization of DNGR-1 in rhesus macaques

Molecular Immunology（2017）

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摘要

•Rhesus macaque DNGR-1 was cloned and has 94.9% sequence identity to that of humans.•Rhesus macaque DNGR-1 could bind dead/damaged cells of both human and rhesus origin.•Rhesus macaque DNGR-1 could recognize cells undergoing pyroptosis.•Rhesus macaque DNGR-1 mRNA was ubiquitous and most abundant in lymphoid tissues.

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关键词

DNGR-1,CLEC9A,Rhesus macaque,Apoptotic cell,Dead cell,Pyroptotic cell,Target

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