A Randomized, Controlled Trial Comparing A Simplified And Standard Regimen For Focal Radiofrequency Ablation Treatment Of Dysplastic Barrett'S Esophagus

Radiofrequency ablation (RFA) is highly effective and durable for the treatment of dysplastic Barrett’s esophagus (BE). Treatment usually consists of a circumferential RFA supplemented by one or more focal RFA sessions. For focal RFA a simplified regimen (3x15J/cm2-no clean) has proven equally effective as the standard (2x15J/cm2-clean-2x15J/cm2) regimen1. Advantages of the simplified regimen include less introductions of the endoscope and shorter procedure time. Unfortunately, this simplified regimen was associated with a higher stricture rate. Therefore, we lowered RF-energy to 12J/cm2 and we now hypothesize that this new simplified regimen (3x12J/cm2-no clean) is as effective and safe as the standard regimen for the treatment of dysplastic BE.