Synthesis, characterization, antifungal activities and crystal structure of thiophene-based heterocyclic chalcones

Heterocyclic chalcones containing thiophene moiety were synthesized and their chemical structures determined via IR, MS, 1H NMR and 13C NMR spectroscopy. Crystal structure of the compounds was determined using single crystal X-ray diffraction.The chalcones were also screened for in-vitro antifungal activity against two fungal strains; Candida albicans (MTCC 3958) and Aspergillus niger (MTCC 9933)which gave good results.