Lurasidone in post-menopausal females with major depressive disorder with mixed features: Post-hoc analysis of a placebo-controlled trial

•We performed post-hoc analysis to assess efficacy of lurasidone by menopausal status.•Post-menopausal and younger females responded significantly versus placebo on MADRS.•Post-menopausal patients had better response than younger patients.•Lurasidone effectively treated MDD in both post-menopausal and younger females.