Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors

Jiayue Xi,Siyuan Xu,Liming Wu,Tianfang Ma,Rongfeng Liu,Yu-Chih Liu,Dawei Deng,Yueqing Gu,Jinpei Zhou,Fei Lan,Xiaoming Zha

Bioorganic Chemistry（2017）

引用 18|浏览7

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摘要

•Synthesis of novel 3-oxoamino-benzenesulfonamides.•7b and 7h showed the best inhibitory activity and high selectivity.•7b and 7h were LSD1 reversible inhibitors.•7b and 7h might be two lead compounds deserved further structural optimization.

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关键词

LSD1,Inhibitors,Selective,Reversible,Docking

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