Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis

Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell , Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N 6 -methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.