Antiproliferative effect of sweet orange peel and its bioactive compounds against human hepatoma cells, in vitro and in vivo

Chin-Chen Chu,Shih-Ying Chen,Charng-Cherng Chyau,Pin-Der Duh

Journal of Functional Foods（2017）

引用 10|浏览7

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摘要

•EESP exhibits a significant cytotoxic effect on hepatoma HepG2 cells.•EESP induces apoptosis of HepG2 cells.•Excessive ROS generated by EESP contributes to apoptosis of HepG2 cells.•Bioactive compounds present in EESP show antiproliferative effect on HepG2 cells.•EESP significantly suppresses the growth of liver tumor xenografts in nude mice.

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关键词

Sweet orange peel,Nobiletin,Tangeretin,Human hepatomacellular carcinoma (HCC),HepG2 cells,Reactive oxygen species,Apoptosis

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