How Well Does CAPTURE Translate?: An Exploratory Analysis of a COPD Case-Finding Method for Spanish-Speaking Patients

Background This study tested the properties of a Spanish translation of CAPTURE (COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk) with selective use of peak expiratory flow (PEF). Methods : This study comprised analyses of data from the Spanish-speaking cohort of the cross-sectional, case-control study used to develop CAPTURE. Translation procedures included forward and backward translation, reconciliation, and cognitive interviewing to assure linguistic and cultural equivalence, yielding CAPTURE-S. Spanish-speaking participants were recruited through one center and designated as case subjects (clinically significant COPD: FEV 1  ≤ 60% predicted and/or at risk of COPD exacerbation) or control subjects (no or mild COPD). Subjects completed a questionnaire booklet that included 44 candidate items, the COPD Assessment Test (CAT), and the modified Medical Research Council (mMRC) dyspnea question. PEF and spirometry were also performed. Results The study included 30 participants (17 case subjects and 13 control subjects). Their mean (± SD) age was 62.6 (11.49) years, and 33% were male. CAPTURE-S scores were significantly correlated with PEF ( r = –0.78), the FEV 1 /FVC ratio ( r = –0.74), FEV 1 ( r = –0.69), FEV 1 % predicted ( r = –0.69), the CAT score ( r = 0.70), and the mMRC dyspnea question ( r = 0.59) ( P t  = 6.16; P 1 ( r = 0.89), FEV 1 % predicted ( r = 0.79), and the FEV 1 /FVC ratio ( r = 0.75) ( P t  = 5.08; P Conclusions CAPTURE-S with selective use of PEF seems to be useful for identifying Spanish-speaking patients in need of diagnostic evaluation for clinically significant COPD who may benefit from initiation of COPD treatment. Trial Registry ClinicalTrials.gov; No.: NCT01880177; URL: www.clinicaltrials.gov.