MP04-18 SMOKING INTENSITY AS A PREDICTOR OF SURVIVAL IN BLADDER CANCER PATIENTS: RESULTS FROM A POPULATION-BASED FLORIDA CANCER REGISTRY (1981-2009)

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I1 Apr 2017MP04-18 SMOKING INTENSITY AS A PREDICTOR OF SURVIVAL IN BLADDER CANCER PATIENTS: RESULTS FROM A POPULATION-BASED FLORIDA CANCER REGISTRY (1981-2009) Luís Felipe Sávio, Tulay Koru-Sengul, Diana M Lopategui, Feng Miao, Nachiketh Soodana Prakash, Bruno Nahar, Vivek Venkatramani, Sanjaya Swain, Sanoj Punnen, Dipen J Parekh, Chad Ritch, and Mark L. Gonzalgo Luís Felipe SávioLuís Felipe Sávio More articles by this author , Tulay Koru-SengulTulay Koru-Sengul More articles by this author , Diana M LopateguiDiana M Lopategui More articles by this author , Feng MiaoFeng Miao More articles by this author , Nachiketh Soodana PrakashNachiketh Soodana Prakash More articles by this author , Bruno NaharBruno Nahar More articles by this author , Vivek VenkatramaniVivek Venkatramani More articles by this author , Sanjaya SwainSanjaya Swain More articles by this author , Sanoj PunnenSanoj Punnen More articles by this author , Dipen J ParekhDipen J Parekh More articles by this author , Chad RitchChad Ritch More articles by this author , and Mark L. GonzalgoMark L. Gonzalgo More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.156AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is limited information regarding the association between smoking intensity and survival trends among patients with bladder cancer (BC). We examined demographic and survival trends for patients diagnosed with BC stratified by smoking intensity. METHODS The Florida Cancer Data System (FCDS) linked with US census data was used to identify all smoking adult patients =18 years residing in Florida diagnosed with BC between 1981 and 2009. Median and 5-year overall survival rates were compared between patients that smoked <1, 1-2, and >2 packs of cigarettes per day (PPD). A multivariable Cox regression model was used to determine the adjusted hazard ratio (AHR) along with 95% confidence interval (95% CI) for mortality after adjustment for age at diagnosis, sex, race, ethnicity, socioeconomic status (SES), marital status, regional lymph node positvity, treatment, grade, and stage of BC. RESULTS Of the 14,077 smoking BC patients, 25%, 63%, and 12% smoked <1, 1-2, and >2 PPD, respectively. The majority of patients were males (74%), Whites (96%), living in an urban area (94%), and with a middle-high/highest SES (53%). The majority of them had localized BC (73%). Median overall survival and 5-year survival rates for the entire cohort were 4.0 years and 43.7% (95%CI: 42.7-44.7), respectively. Median overall survival for patients smoking <1, 1-2, and >2 PPD was 4.2 years, 3.9 years, and 4.1 years, respectively. The 5-year survival rates for patients smoking <1, 1-2, and >2 PPD were 45.1% (43.1-47.1), 43.1% (41.8-44.3), and 43.6% (40.9-46.3), respectively. Patients smoking 1-2 PPD ([HR] 1.11; 95% CI 1.06-1.16, p<0.001) and >2 PPD ([1.08] 1.00-1.16, p=0.042] were significantly more likely to have a higher risk of mortality compared to patients that smoked <1 PPD on multivariate analysis. CONCLUSIONS Higher smoking intensity is associated with an increased risk of mortality among patients with BC. These data highlight the importance of smoking cessation for BC patients and underscore the need for patient education regarding the dangers of smoking. Smoking cessation efforts should be targeted to this population since even a small reduction in the amount of smoking may still have potential survival benefit. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e35 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Luís Felipe Sávio More articles by this author Tulay Koru-Sengul More articles by this author Diana M Lopategui More articles by this author Feng Miao More articles by this author Nachiketh Soodana Prakash More articles by this author Bruno Nahar More articles by this author Vivek Venkatramani More articles by this author Sanjaya Swain More articles by this author Sanoj Punnen More articles by this author Dipen J Parekh More articles by this author Chad Ritch More articles by this author Mark L. Gonzalgo More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...