The direct role of selenocysteine in [NiFeSe] hydrogenase maturation and catalysis

Marta C Marques,Cristina Tapia,Oscar Gutiérrez-Sanz,Ana Raquel Ramos,Kimberly L Keller,Judy D Wall,Antonio L De Lacey,Pedro M Matias,Inês A C Pereira

NATURE CHEMICAL BIOLOGY（2017）

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摘要

Structural and functional characterization of a [NiFeSe] hydrogenase and its conversion to the [NiFe] type by mutagenesis indicate roles for the selenocysteine residue in metal incorporation, catalysis, and protection against oxidative deactivation.

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关键词

Enzyme mechanisms,Enzymes,Metalloproteins,X-ray crystallography,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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