Skin-Directed Electrochemotherapy: A Prospective Multi-Institutional Study On 394 Patients With Superficial Tumors.

e20001 Background: Despite the availability of several skin-directed therapies, cutaneous metastases afflict 1-10% of cancer patients and 45% of those with metastatic melanoma. The basic principle of electrochemotherapy (ECT) relies in administering a poorly permeant cytotoxic agent together with local electric pulses that permeabilize the cell membrane and propel drug molecules into tumors. The goal of this study was to confirm the activity and safety of ECT in a large series; moreover, we evaluated local control, the feasibility of the European Standard Operating Procedures of ECT (ESOPE) and patient quality of life (QoL). Methods: Aprospective, non-randomized, multi-institutional study enrolling patients with unresectable superficial tumors of any histotype who underwent ECT at 10 Italian centers between 2009 and 2013. Treatment outcome included: tumor response, local progression-free survival (LPFS), toxicity (CTC 3.0) and QoL (EORTC QLQ-C30 plus a dedicated questionnaire). Results: A total of 394 pat...