New Aspects Regarding The Induction Chemotherapy With Tpf And Radio Chemotherapy In Head And Neck Cancer.

6025 Background: Induction chemotherapy with docetaxel, cisplatin, and 5 FU (TPF) before radiotherapy (RT) or radio-chemotherapy (RT-CHX) improves the overall survival rate compared to induction chemotherapy with cisplatin and 5 FU in locally advanced squamous cell carcinoma of the head and neck (SCCHN). If TPF induction before RT-CHX improves clinical outcome in comparison to RT-CHX alone is still uncertain. Recently, the results of 5 randomized trials addressing this question have become available. Methods: 1060 patients with locally advanced SCCHN were randomly assigned to receive either TPF induction CHX followed by concurrent RT-CHX or concurrent RT-CHX alone. Platin or taxane based CHX was used during RT. 53,4% of patients had oropharyngeal, 17,3% hyopharyngeal, 6,4% laryngeal, 18,5% oral cavity and 4,4% other SCCHN. Published hazard ratios and hazard ratios extracted from available survival curves for overall survival (OS) and progression free survival (PFS) were basis of the meta-analysis. Meta-an...